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- Title
Foscarnet therapy for severe acyclovir-resistant herpes simplex virus type-2 infections in patients with the acquired immunodeficiency syndrome (AIDS). An uncontrolled trial.
- Authors
Erlich, Kim S.; Jacobson, Mark A.; Koehler, Jane F.; Follansbee, Stephen E.; Drennan, David P.; Gooze, Lisa; Safrio, Sharon; Mills, John; Erlich, K S; Jacobson, M A; Koehler, J E; Follansbee, S E; Drennan, D P; Gooze, L; Safrin, S; Mills, J
- Abstract
<bold>Study Objective: </bold>To determine whether trisodium phosphonoformate (foscarnet) is efficacious in treating severe mucocutaneous disease due to acyclovir-resistant herpes simplex virus type-2 (HSV-2) infection in patients with the acquired immunodeficiency syndrome (AIDS).<bold>Design: </bold>Open-labeled drug administration to patients with AIDS and severe ulcerative disease due to acyclovir-resistant HSV-2 infection.<bold>Setting: </bold>Medical floors of acute care hospital.<bold>Patients: </bold>Four patients with AIDS who developed progressive ulcerative mucocutaneous lesions of the genitals, perineum, perianal region, or finger due to acyclovir-resistant, thymidine-kinase (TK)-negative strains of HSV-2.<bold>Intervention: </bold>Foscarnet, 60 mg/kg body weight intravenously every 8 hours (with reduced dosage for renal impairment), for 12 to 50 days.<bold>Measurement and Main Results: </bold>All patients receiving foscarnet had dramatic improvement in their clinical findings with marked clearing of mucocutaneous lesions and eradication of HSV from mucosal surfaces.<bold>Conclusion: </bold>Foscarnet may be an effective treatment for severe mucocutaneous disease due to acyclovir-resistant, TK-negative strains of HSV-2.
- Subjects
AIDS patients; HERPES simplex virus; ACYCLOVIR; AIDS; ANTIVIRAL agents; CLINICAL trials; COMPARATIVE studies; DRUG resistance in microorganisms; HERPES simplex; INTRAVENOUS therapy; RESEARCH methodology; MICROBIAL sensitivity tests; ORGANOPHOSPHORUS compounds; RESEARCH funding; EVALUATION research; DISEASE complications
- Publication
Annals of Internal Medicine, 1989, Vol 110, Issue 9, p710
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-110-9-710