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- Title
Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.
- Authors
Styczynski, Ashley R.; Malta, Juliane M. A. S.; Krow-Lucal, Elisabeth R.; Percio, Jadher; Nóbrega, Martha E.; Vargas, Alexander; Lanzieri, Tatiana M.; Leite, Priscila L.; Staples, J. Erin; Fischer, Marc X.; Powers, Ann M.; Chang, Gwong-Jen J.; Burns, P. L.; Borland, Erin M.; Ledermann, Jeremy P.; Mossel, Eric C.; Schonberger, Lawrence B.; Belay, Ermias B.; Salinas, Jorge L.; Badaro, Roberto D.
- Abstract
In mid-2015, Salvador, Brazil, reported an outbreak of Guillain-Barré syndrome (GBS), coinciding with the introduction and spread of Zika virus (ZIKV). We found that GBS incidence during April–July 2015 among those ≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those ≥60 years of age. We conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to GBS-symptom onset. A higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (OR 18.1, CI 6.9–47.5), most commonly characterized by rash, headache, fever, and myalgias, within a median of 8 days prior to GBS onset. Our investigation confirmed an outbreak of GBS, particularly in older adults, that was strongly associated with Zika-like illness and geo-temporally associated with ZIKV transmission, suggesting that ZIKV may result in severe neurologic complications.
- Subjects
GUILLAIN-Barre syndrome; ZIKA Virus Epidemic, 2015-2016; ZIKA virus; HEADACHE; FEVER; MYALGIA
- Publication
PLoS Neglected Tropical Diseases, 2017, Vol 11, Issue 8, p1
- ISSN
1935-2727
- Publication type
Article
- DOI
10.1371/journal.pntd.0005869