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- Title
Melatonin concentrations in pineal organ culture are suppressed by sera from tumor-bearing mice.
- Authors
Leone, A. M.; Skene, D.
- Abstract
Leone AM, Skene D. Melatonin concentrations in pineal organ culture are suppressed by sera from tumor-bearing mice. J. Pineal Res. 1994: 17: 17-19. Abstract The melatonin rhythm is significantly attenuated in a wide range of human and animal tumor types. Since surgical removal of the tumor has been shown to restore this rhythm, we hypothesized that a plasma borne tumor-associated factor (TAMF) could be responsible. A population of mice were injected with tumor cells and sequentially killed and bled over the following 9 days, i. e., to the maximal state of tumor growth. Pooled serum from the different collection days was added to an established pineal organ culture system, and melatonin concentrations measured. A highly significant correlation between melatonin concentrations and the stage of tumor growth was seen with maximal inhibition occurring at day 9 ( P < 0. 01). These findings support our hypothesis and may help to explain the mechanism whereby melatonin rhythmicity is suppressed in cancer patients.
- Publication
Journal of Pineal Research, 1994, Vol 17, Issue 1, p17
- ISSN
0742-3098
- Publication type
Article
- DOI
10.1111/j.1600-079X.1994.tb00108.x