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- Title
TPO- RAs in pITP: description of a case series and analysis of predictive factors for response.
- Authors
Mazzucconi, Maria Gabriella; Santoro, Cristina; Baldacci, Erminia; De Angelis, Federico; Chisini, Marta; Ferrara, Grazia; Volpicelli, Paola; Foà, Roberto
- Abstract
Objective To report our experience concerning sustained response ( SR) after TPO- RA discontinuation in adult pITP patients and to identify possible predictive factors for outcome. Methods Thirty-nine pITP patients who received a TPO- RA were evaluated. Response (R) was defined as a platelet count ≥30 × 109/L and at least a twofold increase in the baseline count and complete response ( CR) as a platelet count ≥100 × 109/L, in the absence of bleeding. Durable response ( DR) was defined as a R/ CR persisting ≥4 wk with a stable dose of TPO- RA, and SR as the first assessed platelet count ≥30 × 109/L, available at more than 4 wk after discontinuation of TPO- RA, in the absence of other concomitant or rescue therapies. Results Twenty-nine/39 (74%) were responders: 18 (46%) reached a CR and 11 (28%) a R. A DR was observed in 16/29 (55%) responders. Seven SR (18%) were reached: five of seven patients achieved a SR from a prior DR. CR was statistically associated with the achievement of a subsequent DR: 13/18 (72%) CR patients obtained a DR, while only three of 11 (27%) R ones did ( P = 0.027). Conclusions CR was a significant prognostic factor for the achievement of a DR. Moreover, we observed a trend for DR patients to obtain a subsequent SR.
- Subjects
THROMBOPOIETIN receptors; IDIOPATHIC thrombocytopenic purpura; PLATELET count; CHEMICAL agonists; HEALTH outcome assessment; THERAPEUTICS
- Publication
European Journal of Haematology, 2017, Vol 98, Issue 3, p242
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.12822