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- Title
Clinical improvement and survival in breast cancer leptomeningeal metastasis correlate with the cytologic response to intrathecal chemotherapy.
- Authors
Clatot, Florian; Philippin-Lauridant, Géraldine; Ouvrier, Matthieu-John; Nakry, Tony; Laberge-Le-Couteulx, Sophie; Guillemet, Cécile; Veyret, Corinne; Blot, Emmanuel
- Abstract
Leptomeningeal meningitis occurs in approximately 5% of metastatic breast cancers, and there is no standard treatment for this complication. We retrospectively analyzed the clinical data and cerebrospinal fluid of 24 patients treated with high-dose intrathecal methotrexate for breast cancer leptomeningeal meningitis (BLM). Cytologic response (CSF cytology without neoplastic cells after treatment) was observed in 11 patients (46%) and related to survival ( P = 0.005). In addition, clinical symptoms improved in all 11 patients who had a cytologic response and in 7 patients (54%) without cytologic response ( P = 0.02). The predictive value of cytologic response needs further confirmation. Cytologic response could be helpful in the management of intrathecal chemotherapy in patients with BLM.
- Subjects
MENINGITIS treatment; BREAST cancer patients; DRUG therapy; METHOTREXATE; RETROSPECTIVE studies; CEREBROSPINAL fluid proteins; PROGNOSIS; CELLULAR pathology
- Publication
Journal of Neuro-Oncology, 2009, Vol 95, Issue 3, p421
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-009-9940-2