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- Title
Morita-Baylis-Hillman Approach toward Formal Total Synthesis of Tamiflu and Total Synthesis of Gabaculine.
- Authors
Bhowmik, Subhendu; Batra, Sanjay
- Abstract
A Morita-Baylis-Hillman reaction mediated approach to the formal total synthesis of oseltamivir and the total synthesis of gabaculine is described. This strategy involves the enantiocontrolled preparation of Corey's intermediate in 22 % yield, which is prepared over 11 steps starting from N- tert-butoxycarbonyl- L-serine methyl ester.
- Subjects
DRUG synthesis; OSELTAMIVIR; PHARMACEUTICAL chemistry; ANTIVIRAL agents; AMINO acids
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 31, p7145
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300977