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- Title
Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?
- Authors
Eijsvoogel, Noortje B.; Hollegien, Mirjam I.; Bok, Vinus L. A.; Derksen−Lubsen, Arda G.; Dikken, Felix P. J.; Leenders, Sander A. C. A. P.; Pijning, Arjan.; Post, Erica; Wojciechowski, Marek; Hilbink, Mirrian; de Vries, Esther
- Abstract
We determined the anti-HBs titer in 227 children of all ages with Down syndrome (DS). Only 48.1% (95%CI: 35.1-61.3) of the DS children aged 7-10 years and 31.9% (95%CI: 22.1-43.6) of the DS children aged >10 years had a protective anti-HBs titer (≥10 IU/L). The geometric mean anti-HBs titer was significantly lower in the DS children; this suggests booster vaccination for HBV may be needed.
- Publication
Journal of Medical Virology, 2017, Vol 89, Issue 9, p1682
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.24813