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- Title
Assessment of clinical risk predictive rules for invasive candidiasis in a prospective multicentre cohort of ICU patients.
- Authors
Playford, Elliott Geoffrey; Lipman, Jeff; Kabir, Masrura; McBryde, Emma S.; Nimmo, Graeme R.; Lau, Anna; Sorrell, Tania C.
- Abstract
To assess the generalisability of published clinical risk predictive models for invasive candidiasis in ICU patients. The performance characteristics of published clinical risk factor-only and Candida colonisation-only predictive models for invasive candidiasis were assessed in a multicentre cohort of Australian ICU patients. Clinical risk factors and Candida colonisation parameters were collected prospectively from patients. The two clinical risk factor-only predictive models applied to an Australian patient cohort ( n = 615) performed less well than in published studies involving derivation populations. Model performance characteristics improved when Candida colonisation parameters were added post-hoc. Risk predictive models should factor in both clinical risk factors and Candida colonisation parameters. Integrating these models into therapeutic algorithms first requires external validation in different patient populations and settings.
- Subjects
CRITICAL care medicine; INTENSIVE care units; DISEASE risk factors; CANDIDIASIS; MYCOSES
- Publication
Intensive Care Medicine, 2009, Vol 35, Issue 12, p2141
- ISSN
0342-4642
- Publication type
Report
- DOI
10.1007/s00134-009-1619-9