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- Title
Novel Orthobunyavirus Identified in the Cerebrospinal Fluid of a Ugandan Child With Severe Encephalopathy.
- Authors
Edridge, Arthur W D; Deijs, Martin; Namazzi, Ruth; Cristella, Cosimo; Jebbink, Maarten F; Maurer, Irma; Kootstra, Neeltje A; Buluma, Linda R; Woensel, Job B M van; Jong, Menno D de; Idro, Richard; Hensbroek, Michael Boele van; van der Hoek, Lia
- Abstract
A Ugandan child with an unexplained encephalitis was investigated using viral metagenomics. Several sequences from all segments of a novel orthobunyavirus were found. The S-segment, used for typing, showed 41% amino acid diversity to its closest relative. The virus was named Ntwetwe virus, after the hometown of the patient.
- Subjects
UGANDA; DIAGNOSIS of brain diseases; BRAIN diseases; CEREBROSPINAL fluid examination; VIRAL disease diagnosis; AMINO acids; RNA viruses; SEVERITY of illness index; SEQUENCE analysis; GENETICS
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 1, p139
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy486