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- Title
Association of chronic plaque psoriasis and severe periodontitis: a hospital based case-control study.
- Authors
Lazaridou, E.; Tsikrikoni, A.; Fotiadou, C.; Kyrmanidou, E.; Vakirlis, E.; Giannopoulou, C.; Apalla, Z.; Ioannides, D.
- Abstract
Background Both chronic plaque psoriasis and periodontitis have an increasing prevalence worldwide and have been associated with the metabolic syndrome; however limited information is available on their association. Objective To evaluate the possible association of severe periodontitis and chronic plaque psoriasis. Methods This was a hospital based case-control study. Chronic plaque psoriasis patients and age- and gender-matched controls have been recruited. Baseline demographic data have been recorded. To explore correlations between different dichotomous variables the Sperman Rho correlation coefficient was used. Correlations were further explored non-parametrically and univariate and multivariate logistic regression was utilized after adjustment for the effect of confounders. Results During the study enrolment period 100 patients with CPP and 100 age- and gender-matched controls were included in this study. Mean age for both groups was 57.2 ± 5.3 years. 43% of patients and controls were males. Significant correlations where noted between psoriasis and 1) periodontitis (rho = 0.219, P = 0.02) and 2) metabolic syndrome (rho = 0.191, P = 0.07) using Spearman's Rho correlation co-efficient. Univariate logistic regression reported significant relations between psoriasis and periodontitis (OR = 3.329, 95%CI: 1.513-7.324, P = 0.003) and psoriasis and metabolic syndrome (OR = 2.293, 95%CI: 1.250-4.207, P = 0.007). On the contrary, a non-significant relation between psoriasis and active smoking status was detected (OR = 1.041, 95%CI: 0.597-1.817, P = 0.887). In a multivariate analysis model we found a significant correlation of psoriasis and periodontitis when controlled for the presence of metabolic syndrome (OR: 2.486, 95%CI: 1.002-5.842, P = 0.049). Conclusion Periodontitis may be associated with psoriasis but further studies are required to elucidate their relationship in the context of the biologic plausibility.
- Subjects
PSORIASIS treatment; CHRONIC diseases; PERIODONTITIS; METABOLIC syndrome; PSORIASIS; AGE groups; PLAUSIBILITY (Logic); PATIENTS
- Publication
Journal of the European Academy of Dermatology & Venereology, 2013, Vol 27, Issue 8, p967
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2012.04615.x