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- Title
E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions
- Authors
Carneiro, Patrícia; Fernandes, Maria Sofia; Figueiredo, Joana; Caldeira, Joana; Carvalho, Joana; Pinheiro, Hugo; Leite, Marina; Melo, Soraia; Oliveira, Patrícia; Simões-Correia, Joana; Oliveira, Maria José; Carneiro, Fátima; Figueiredo, Céu; Paredes, Joana; Oliveira, Carla; Seruca, Raquel
- Abstract
Abstract: E-cadherin plays a major role in cell–cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families.
- Subjects
HEREDITARY diffuse gastric cancer; CADHERINS; CANCER cells; CELL adhesion; CANCER invasiveness; CELLULAR signal transduction; CARCINOGENESIS
- Publication
FEBS Letters, 2012, Vol 586, Issue 18, p2981
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.07.045