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- Title
Severe acute propafenone poisoning - diagnosis and therapeutic approaches.
- Authors
Vivisenco1, Cristina Iolanda; Ulmeanu, Coriolan Emil
- Abstract
Propafenone is an antiarrhythmic drug which blocks myocardial sodium channels as the main mechanism of action. Ingestion of a toxic dose of propafenone induces through the membrane stabilizing effect a clinical presentation with cardiovascular, neurological and metabolic expression, sometimes life-threatening. The authors present the case of a 13 year old female patient admitted for cardiac conduction abnormalities, seizures and coma after intentional ingestion of a toxic dose of propafenone. The patient was successfully treated with intravenous sodium bicarbonate therapy and supportive measures. The authors mention also the latest information from the literature regarding the management of propafenone poisoning.
- Subjects
PROPAFENONE; MYOCARDIAL depressants; SODIUM channels; BIOCHEMICAL mechanism of action; HEART conduction system; DRUG side effects; SEIZURES in children; DISEASES
- Publication
Romanian Journal of Pediatrics / Revista Romana de Pediatrie, 2013, Vol 62, Issue 3, p302
- ISSN
1454-0398
- Publication type
Article