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- Title
Predictive value of skin invasion in recurrent head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using a cyberknife.
- Authors
Hideya Yamazaki; Mikio Ogita; Kengo Himei; Satoaki Nakamura; Gen Suzuki; Tadayuki Kotsuma; Ken Yoshida; Yasuo Yoshioka; Yamazaki, Hideya; Ogita, Mikio; Himei, Kengo; Nakamura, Satoaki; Suzuki, Gen; Kotsuma, Tadayuki; Yoshida, Ken; Yoshioka, Yasuo
- Abstract
<bold>Background: </bold>This study aimed to elucidate the influence of skin invasion in patients with recurrent head and neck cancer treated with re-irradiation using stereotactic radiotherapy.<bold>Materials: </bold>We reviewed 104 patients treated using CyberKnife in four institutions.<bold>Results: </bold>Nine cases of skin invasion were recognized (8.6 %). Larger tumors tended to exhibit skin invasion. The skin invasion (+) group showed a lower response rate (0/9, 0 %) than the skin invasion (-) group (56/95, 59 %) (p = 0.002). The skin invasion (+) group showed lower local control (LC) and progression free survival (PFS) rates, both 0 % at 6 months, than the skin invasion (-) group, which had a LC of 69 % (p = 0.0001) and a PFS of 48 % at 1 year (p = 0.0157). Median survival time and one-year survival rates for the skin invasion (+) and (-) groups were 6.6 vs. 15.3 months and 14 % vs. 59 % (p = 0.0005), respectively. No patient with skin invasion survived more than 14.4 months. The percentage of patients who developed grade 3 or higher toxicity was 44 % in the skin invasion (+) group and 18 % in the skin invasion (-) group (p = 0.14).<bold>Conclusions: </bold>Skin invasion is an important predictor of poor prognosis in recurrent head and neck cancer after re-irradiation with stereotactic radiation therapy.
- Subjects
HEAD &; neck cancer; STEREOTACTIC radiotherapy; IRRADIATION; SKIN tumors; PROGNOSIS; INTENSITY modulated radiotherapy; IMAGE-guided radiation therapy; CANCER relapse; HEAD tumors; NECK tumors; RADIOSURGERY; RETROSPECTIVE studies; KAPLAN-Meier estimator; SURGERY
- Publication
Radiation Oncology, 2015, Vol 10, Issue 1, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-015-0517-2