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- Title
Mutations in the Insulin-Like Factor 3 Receptor Are Associated With Osteoporosis.
- Authors
Ferlin, Alberto; Pepe, Anastasia; Gianesello, Lisa; Garolla, Andrea; Shu Fen; Giannini, Sandro; Zaccolo, Manuela; Facciolli, Arianna; Morello, Roy; Agoulnik, Alexander I.; Foresta, Carlo
- Abstract
The article presents a study which evaluates whether reduced insulin-like factor 3 (INSL3) activity could cause or contribute to some signs of hypogonadism which is attributed to testosterone deficiency. Researchers have conducted a series of tests to young adults with T222P mutation in the RXFP2 gene to clarify the potential endocrine roles of INSL3. Results reveal that INSL3/RXFP2 signaling plays a role in bone metabolism and that RXFP2 gene mutations is linked with osteoporosis.
- Subjects
SOMATOMEDIN; HYPOGONADISM; BONE metabolism; GENETIC mutation; OSTEOPOROSIS; BONES
- Publication
Journal of Bone & Mineral Research, 2008, Vol 23, Issue 5, p683
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.080204