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- Title
The use of CO<sub>2</sub> laser in vulvar lichen sclerosus treatment - molecular evidence.
- Authors
Marzec, Adrianna; Olejek, Anita; Stopinska, Kamila; Cnota, Wojciech; Gabriel, Iwona
- Abstract
Objectives: Vulvar lichen sclerosus is chronic and difficult to treat disorder, which often is recurrent and leads to multiple complications. The limited efficacy of pharmacologic treatment directed the search for new therapies including use of CO2 laser. The aim of the study was to provide rationale for the use of CO2 laser in treatment of vulvar lichen sclerosus. Material and methods: Two patients with diagnosed LS were recruited for the study. Vulvar biopsies were taken taken before CO2 laser application and then 3 months later. We assessed the following genes: COL1A, COL1A2, COL3A1, COL5A1, COL5A2, COL5A3, ELN, ECM1, HSPA1A, HSPA1B, SERPINH1, TLL1, TP53, BMP1. We also assessed patients' quality of life by VuAS scale before and after treatment. Results: In both patients we observed decreased clinical symptoms observed by an experienced gynecologist as well as significant changes in gene expression before and after laser treatment. Conclusions: Treatment with CO2 laser can be alternatively considered in patients with vulvar lichen sclerosus.
- Subjects
VULVAR diseases; PHARMACOLOGY; GYNECOLOGISTS; LASERS; BIOPSY
- Publication
Ginekologia Polska, 2023, Vol 94, Issue 11, p903
- ISSN
0017-0011
- Publication type
Article
- DOI
10.5603/GP.a2023.0044