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- Title
Functional Specialization of Parallel Motion Detection Circuits in the Fly.
- Authors
Joesch, Maximilian; Weber, Franz; Eichner, Hubert; Borst, Alexander
- Abstract
In the fly Drosophila melanogaster, photoreceptor input to motion vision is split into two parallel pathways as represented by first-order interneurons LI and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways are functionally specialized remains controversial. One study (Eichner et al., 2011 ) proposed that the LI -pathway evaluates only sequences of brightness increments (ON-ON), while the L2-pathway processes exclusively brightness decrements (OFF-OFF). Another study (Clark et al., 2011 ) proposed that each of the two pathways evaluates both ON-ON and OFF-OFF sequences. To decide between these alternatives, we recorded from motion-sensitive neurons in flies in which the output from either LI or L2 was genetically blocked. We found that blocking LI abolishes ON-ON responses but leaves OFF-OFF responses intact. The opposite was true, when the output from L2 was blocked. We conclude that the LI and L2 pathways are functionally specialized to detect ON-ON and OFF-OFF sequences, respectively.
- Subjects
NEURAL circuitry; PHOTORECEPTORS; DROSOPHILA melanogaster; INTERNEURONS; NEURONS; BRAIN function localization; BEHAVIOR
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 3, p902
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3374-12.2013