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- Title
Effectiveness of Human Papillomavirus (HPV) Vaccination Against Penile HPV Infection in Men Who Have Sex With Men and Transgender Women.
- Authors
Winer, Rachel L; Lin, John; Querec, Troy D; Unger, Elizabeth R; Stern, Joshua E; Rudd, Jessica M; Golden, Matthew R; Swanson, Fred; Markowitz, Lauri E; Meites, Elissa
- Abstract
<bold>Background: </bold>In the United States, human papillomavirus (HPV) vaccination has been recommended since 2011 for boys aged 11-12 years, with catch-up vaccination recommended through age 26 years for previously unvaccinated men who have sex with men (MSM).<bold>Methods: </bold>During 2016-2018, a cross-sectional study enrolled MSM and transgender women aged 18-26 years in Seattle, Washington. Participants submitted self-collected penile swab specimens for HPV genotyping. HPV vaccination history was self-reported. We compared HPV prevalence among vaccinated participants with that in participants with no or unknown vaccination history, using log-binomial regression to estimate adjusted prevalence ratios and confidence intervals.<bold>Results: </bold>Among 687 participants, 348 (50.7%) self-reported ever receiving ≥1 HPV vaccine dose; the median age at first HPV vaccination was 21 years, and the median age at first sex, 17 years. Overall, the prevalence of penile quadrivalent HPV vaccine (4vHPV)-type HPV was similar in vaccinated participants (12.1%) and participants with no or unknown vaccination (15.6%) (adjusted prevalence ratio, 0.69 [95% confidence interval, .47-1.01]). However, the prevalence was significantly lower in participants vaccinated at age ≤18 years than in those with no of unknown vaccination (0.15 [.04-.62]), corresponding to a vaccine effectiveness of 85% against 4vHPV-type HPV.<bold>Conclusions: </bold>Results suggest that HPV vaccination is effective in preventing penile HPV infections in young MSM when administered at age ≤18 years.
- Subjects
SEATTLE (Wash.); TRANSGENDER people; VACCINATION status; VACCINE effectiveness; VACCINATION; PAPILLOMAVIRUSES
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 3, p422
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab390