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- Title
Urban Particulate Matter Impairment of Airway Surface Liquid-Mediated Coronavirus Inactivation.
- Authors
Stapleton, Emma M; Welch, Jennifer L; Ubeda, Erika A; Xiang, Jinhua; Zabner, Joseph; Thornell, Ian M; Nonnenmann, Matthew W; Stapleton, Jack T; Comellas, Alejandro P
- Abstract
Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.
- Subjects
PARTICULATE matter; INDOOR air pollution; COVID-19; COMMON cold; VOLCANIC ash, tuff, etc.
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 2, p214
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab545