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- Title
Genetic Background Amplifies the Effect of Immunodeficiency in Antibiotic Efficacy Against Borrelia burgdorferi.
- Authors
Sharma, Bijaya; McCarthy, Julie E; Freliech, Cecily A; Clark, Morgen M; Hu, Linden T
- Abstract
Unrecognized immunodeficiency has been proposed as a possible cause of failure of antibiotics to resolve symptoms of Lyme disease. Here, we examined the efficacy of doxycycline in different immunodeficient mice to identify defects that impair antibiotic treatment outcomes. We found that doxycycline had significantly lower efficacy in the absence of adaptive immunity, specifically B cells. This effect was most pronounced in immunodeficient C3H mice compared with C57BL/6 mice, suggesting a role for genetic background beyond immunodeficiency. Addition of a single dose of ceftriaxone to doxycycline treatment effectively cleared infection in C3H mice with severe combined immunodeficiency.
- Subjects
BORRELIA burgdorferi; SEVERE combined immunodeficiency; ANTIBIOTICS; LABORATORY mice; LYME disease; CD20 antigen
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 2, p345
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa719