We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Potency and recovery characteristics of rocuronium mixed with sodium bicarbonate.
- Authors
Lee, H. J.; Kim, K. S.; Yeon, J. T.; Suh, J. K.; Sung, I. H.; Shin, I. C.
- Abstract
Sodium bicarbonate may be added to rocuronium to decrease pain on injection. However, this mixture may result in the formation of carbon dioxide bubbles. We investigated whether the addition of sodium bicarbonate to rocuronium alters neuromuscular blockade, in 120 patients randomly assigned to receive rocuronium mixed with saline or bicarbonate 8.4%, either in varying doses (for dose-response measurements; 60 patients) or a fixed dose of 600 μg.kg-1 (for time-course measurements; 60 patients). Sodium bicarbonate resulted in a left-shift of the rocuronium dose-response curve. The effective doses of rocuronium to produce 95% twitch depression were 331.6 (95% CI: 310.4–352.8) and 284.3 (95% CI: 262.0–306.6) μg.kg−1 mixed with isotonic saline or sodium bicarbonate, respectively (p < 0.001). The mean (SD) onset times of rocuronium 600 μg.kg-1 were 3.6 (0.6) and 2.7 (0.5) min in the corresponding groups, respectively (p < 0.001). The mean (SD) times to 95% recovery were 35.8 (5.8) and 47.9 (7.1) min, respectively (p < 0.001). We conclude that the mixing of sodium bicarbonate with rocuronium enhances the potency, shortens the onset and prolongs the duration of action.
- Subjects
SODIUM bicarbonate; BUBBLES; NEUROMUSCULAR blocking agents; SALINE solutions; DOSE-response relationship in poisons; THERAPEUTICS
- Publication
Anaesthesia, 2010, Vol 65, Issue 9, p899
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2010.06380.x