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- Title
Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation.
- Authors
Nagy, Akos; Nagashima, Hiroyuki; Cha, Seunghee; Oxford, Gregory E.; Zelles, Tivadar; Peck, Ammon B.; Humphreys-Beher, Michael G.; Nagy, A; Nagashima, H; Cha, S; Oxford, G E; Zelles, T; Peck, A B; Humphreys-Beher, M G
- Abstract
Using the NOD mouse, a model for type 1 diabetes, we examined how reduced concentrations of epidermal growth factor (EGF) in the saliva, after onset of type 1 diabetes, affect oral wound healing. Diabetic NOD/LtJ mice on insulin therapy, prediabetic NOD/LtJ, and age- and sex-matched BALB/cJ mice were given a cutaneous tongue punch and allowed to undergo normal healing. With diabetes onset and a reduction in saliva-derived growth factor levels, the rate of tongue wound healing was reduced compared with nondiabetic NOD/LtJ and healthy BALB/cJ mice. Addition of exogenous EGF to the drinking water did not accelerate the rate of healing in BALB/cJ or prediabetic NOD/LtJ; however, diabetic NOD/LtJ mice exhibited accelerated wound healing similar to healthy mice. These results demonstrate that loss of growth factors from saliva is associated with profoundly reduced oral wound healing, suggesting that therapeutic treatment with topical delivery may be beneficial to patients with type 1 diabetes and oral wound complications.
- Subjects
EPIDERMAL growth factor; DIABETES; MICE physiology; RNA metabolism; ANIMAL experimentation; ANTHROPOMETRY; BODY weight; COMPARATIVE studies; HOMEOSTASIS; TYPE 1 diabetes; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; TONGUE; WOUND healing; WOUNDS &; injuries; EVALUATION research
- Publication
Diabetes, 2001, Vol 50, Issue 9, p2100
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.50.9.2100