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- Title
Ascertainment Bias in TB Treatment Trials Can Systematic Assessment of Objective Endpoints Solve It?
- Authors
Mitnick, Carole D.; Nunn, Andrew J.
- Abstract
The article discusses the challenges of conducting unbiased treatment trials for tuberculosis (TB) when there is limited microbiological data available. The authors propose a standardized approach called "poor treatment response (PPTR)" to reduce ascertainment bias in noninferiority trials. It mentions that the PPTR approach involves specific triggers for assessing poor treatment response and standardized procedures for evaluation, including sputum sample collection.
- Subjects
TUBERCULOSIS; MULTIDRUG-resistant tuberculosis
- Publication
American Journal of Respiratory & Critical Care Medicine, 2023, Vol 207, Issue 10, p1269
- ISSN
1073-449X
- Publication type
Article
- DOI
10.1164/rccm.202303-0430ED