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- Title
Autonomic nervous system dysfunction and serum levels of neurotoxic and neurotrophic cytokines in patients with cobalamin deficiency.
- Authors
Çeneli, Özcan; Akı, şahika Zeynep; Küçük, Betül Çevik; Tokçaer, Ayşe Bora; Kuruoğlu, Reha; Yağcğ, Münci
- Abstract
Objective: The imbalance between neurotoxic cytokine tumor necrosis factor-α(TNF-α) and neurotrophic cytokines epidermal growth factor (EGF) and interleukin-6 (IL-6) plays a role in the pathogenesis of cobalamin (Cbl) deficiency-induced neuropathy. The aim of this study was to evaluate autonomic nervous system dysfunction and to look for any relationship between autonomic nervous system disturbances and serum cytokine levels (TNF-α, EGF, IL-6) in patients with Cbl deficiency. Materials and Methods: Serum levels of TNF-α, EGF and IL-6 were studied in patients with Cbl deficiency (n=41) and a healthy control group (n=17) and after 3 months in patients who underwent Cbl replacement therapy (n=22). All patients with Cbl deficiency underwent electrophysiological studies (EPS) for the diagnosis of neuropathy. Statistical analysis was performed using SPSS for Windows 11.5 software. Results: With EPS, 29 of 41 Cbl-deficient patients (70.73%) demonstrated neurological dysfunction [3 (7.32%), 19 (46.34%) and 7 (17.07%) patients with sensorimotor peripheral neuropathy, parasympathetic, and sympathetic autonomic dysfunction, respectively]. Although there was no significant difference in serum levels of EGF and IL-6 between patients with versus without autonomic dysfunction, levels were significantly lower in Cbl- deficient patients than healthy controls. Conclusion: Presence of autonomic dysfunction seems to be a frequent neurological finding in patients with Cbl deficiency. However, we could not find any relationship between serum cytokine levels and autonomic dysfunction by EPS.
- Subjects
ANALYSIS of variance; AUTONOMIC nervous system diseases; COMPUTER software; STATISTICAL correlation; ELECTROPHYSIOLOGY; ENZYME-linked immunosorbent assay; EPIDERMAL growth factor; INTERLEUKINS; STATISTICS; T-test (Statistics); TUMOR necrosis factors; U-statistics; VITAMIN B12 deficiency; DATA analysis; DISEASE complications
- Publication
Turkish Journal of Hematology, 2010, Vol 27, Issue 4, p250
- ISSN
1300-7777
- Publication type
Article
- DOI
10.5152/tjh.2010.46