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- Title
Preventing early-onset group B streptococcal sepsis: clinical risk factor-based screening or culture-based screening?
- Authors
Jiun Lee; Naiduvaje, Krishnamoorthy; Ka Lip Chew; Charan, Natasha; Yiong Huak Chan; Tzer-Pin Lin, Raymond; Eu Leong Yong; Lee, Jiun; Chew, Ka Lip; Chan, Yiong Huak; Lin, Raymond Tzer-Pin; Yong, Eu Leong
- Abstract
<bold>Introduction: </bold>Two strategies are available for prevention of early-onset group B streptococcal (GBS) sepsis - clinical risk factor-based screening and routine culture-based screening of pregnant women for GBS colonisation. In our hospital, we switched from the former to the latter approach in 2014.<bold>Methods: </bold>We compared the incidence of early-onset GBS sepsis during 2001-2015 between infants born to pregnant women who were screened for GBS colonisation and those born to women who were not screened.<bold>Results: </bold>Among 41,143 live births, there were nine cases of early-onset GBS sepsis. All infants with GBS sepsis were born to pregnant women who were not screened for GBS colonisation. The incidence of early-onset GBS sepsis among infants of women who were not screened was 0.41 per 1,000 live births (95% confidence interval [CI] 0.19-0.77) when compared to infants of women who were screened, for whom the sepsis incidence was zero per 1,000 live births (95% CI 0-0.19; p = 0.005).<bold>Conclusion: </bold>Our data suggests that routine culture-based screening of pregnant women for GBS colonisation is a better preventive strategy for early-onset GBS sepsis in neonates when compared to clinical risk factor-based screening.
- Subjects
SEPSIS; NEONATAL diseases; PREGNANT women; CONFIDENCE intervals; NEWBORN infants; COLONIZATION
- Publication
Singapore Medical Journal, 2021, Vol 62, Issue 1, p34
- ISSN
0037-5675
- Publication type
journal article
- DOI
10.11622/smedj.2019155