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- Title
Reduced ratio of eicosapentaenoic acid and docosahexaenoic acid to arachidonic acid is associated with early onset of acute coronary syndrome.
- Authors
Shusuke Yagi; Ken-ichi Aihara; Daiju Fukuda; Akira Takashima; Mika Bando; Tomoya Hara; Sachiko Nishimoto; Takayuki Ise; Kenya Kusunose; Koji Yamaguchi; Takeshi Tobiume; Takashi Iwase; Hirotsugu Yamada; Takeshi Soeki; Tetsuzo Wakatsuki; Michio Shimabukuro; Masashi Akaike; Masataka Sata; Yagi, Shusuke; Aihara, Ken-Ichi
- Abstract
<bold>Background: </bold>The hospitalization rate for acute coronary syndrome (ACS) for people aged ≤50 has remained stable over the past decade. Increased serum levels of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with a decreased incidence of cardiovascular events and mortality in older patients; however, it is currently unknown whether reduced serum levels of n-3 PUFAs is also a risk factor for ACS in patients aged ≤50 years.<bold>Methods and Results: </bold>We retrospectively reviewed 102 (male/ female 73/29) Japanese ACS patients whose serum levels of EPA/arachidonic acid (AA) and DHA/AA were evaluated on admission. The EPA/AA ratio was the lowest in patients aged ≤50 compared to patients aged 51-74 and ≥75. Pearson correlation analysis showed that early ACS onset was associated with low EPA/AA and DHA/AA ratios, and multiple regression analysis determined that decreased ratios of EPA/AA and DHA/AA, and male sex, current smoker status, increased body mass index and triglyceride levels, independently correlated with early ACS onset. Conversely, low-density and high-density lipoproteins, glycated hemoglobin, and hypertension did not correlate with early ACS onset. Subgroup analyses of male patients revealed that decreased ratios of EPA/AA and DHA/AA independently correlated with early ACS onset.<bold>Conclusion: </bold>Decreased EPA/AA and DHA/AA ratios may be risk factors for early onset of ACS, suggesting that reduced EPA/AA and DHA/AA may represent targets for preventing ACS in Japanese young people.
- Subjects
JAPAN; ARACHIDONIC acid; DOCOSAHEXAENOIC acid; EICOSAPENTAENOIC acid; RETROSPECTIVE studies; ACUTE coronary syndrome
- Publication
Nutrition Journal, 2015, Vol 14, p1
- ISSN
1475-2891
- Publication type
journal article
- DOI
10.1186/s12937-015-0102-4