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- Title
Transarterial Chemoembolization With Lipiodal For Unresectable Hepatocellular Carcinoma.
- Authors
Pannag Desai, K. N.; Indusekhar, S.; Vidya Bhargavi, R.
- Abstract
Aims & Objectives: To evaluate response and survival outcomes in unresectable HCC patients treated with TACE in a tertiary care oncology hospital at Bangalore. Methods and Materials: Clinical, laboratory and radiological data of all patients undergoing Transarterial Chemoembolization (TACE) with Lipiodol for treatment of hepatocellular carcinoma, presenting to HCG Hospital, Bangalore between January 2013 and December 2016 were collected. Post TACE follow up details to assess response was tabulated. The tumor response was classified based on mRECIST Criteria. The overall survival of the patient was assessed from the date of diagnosis until death, loss to follow up or status at the time of data collection. Results: A total of 78 patients (71 males, 7 females; mean age 62.5 ± 11.7 years) undergoing 126 TACE procedures were included in the study. The Child's classification was: A - 61 patients and B - 17 patients. Barcelona Clinic staging was: A - 8 patients, B - 59 patients, and C - 11 patients. The overall survival (OS) was 21.65 ± 1.6 months at the end of 3 year follow up. 33, 24 and 21 patients had partial response (PR), stable disease (SD) and progressive disease (PD) respectively. The overall survival was 24.7 ± 2.4, 23.3 ± 3.0 and 15.8 ± 2.5 months among PR, SD and PD groups respectively. 15, 33, 21 and 9 patients had Type 1, 2, 3 & 4 lipiodol depositions. The overall survival was 31.1 ± 1.5, 21.8 ± 2.5, 13.1 ± 1.5 and 13.7 ± 1.6 months among lipiodol deposition type 1, 2, 3 & 4 groups respectively. Conclusions: TACE resulted in significant reduction of tumor bulk. The degree of lipiodol accumulation is a prognostic factor in patients with unresectable HCC. Tumor response based on mRECIST combined with complete lipiodol deposition was better for identification of major tumor necrosis.
- Subjects
BENGALURU (India); BARCELONA (Spain); CHEMOEMBOLIZATION; HEPATOCELLULAR carcinoma; TERTIARY care; ACQUISITION of data
- Publication
Journal of Cancer Research & Therapeutics, 2017, Vol 13, pS192
- ISSN
0973-1482
- Publication type
Article