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- Title
Nutritional Zinc Status in Weaning Infants: Association with Iron Deficiency, Age, and Growth Profile.
- Authors
Park, Jeong; Chang, Ju; Hong, Jeana; Ko, Jae; Seo, Jeong; Shin, Sue; Lee, Eun
- Abstract
In the present study, we evaluated the correlation between iron deficiency (ID) and zinc deficiency (ZD) and explored the demographic, anthropometric, and feeding-related factors associated with hypozincemia and hair zinc content in weaning infants. Infants aged 6-24 months were recruited, their feeding history was recorded, and their heights and weights were measured. Hemoglobin content, serum iron/total iron-binding capacity, and ferritin and zinc concentrations of serum and hair (using inductively coupled plasma-mass spectroscopy) were assessed. Among 101 infants, 64 (63.4 %) infants exhibited ID. The median serum zinc concentration in iron-deficient infants was lower than that in non-iron-deficient infants, respectively, 73.5 μg/dL (interquartile range [IQR], 65.0-83.8) vs. 87.0 μg/dL (IQR, 77.5-97.0; p = 0.001). The frequency of hypozincemia was also significantly higher in the iron-deficient group than in the non-iron-deficient group (21 out of 64 [32.8 %] vs. 4 out of 37 [10.8 %], respectively; p = 0.014). In multiple regression analysis, the risk of hypozincemia was significantly increased in infants with ID ( p = 0.026), mildly underweight infants (weight-for-age Z score < −1; p = 0.034), and infants with mild wasting (weight-for-height Z score < −1; p = 0.028). Hair zinc concentrations ( n = 81) were not significantly associated with ID status ( p > 0.1); however, there was an inverse relationship between hair zinc concentrations and age of infants ( r = −0.250; p = 0.024). In weaning infants, ID is a risk factor for hypozincemia. Hair zinc concentrations appeared to decrease as the age of infants increased during late infancy. Further large-scale studies are needed to validate the relationship between hypozincemia and mild degrees of weight gain impairment in this age group.
- Subjects
IRON deficiency; ZINC deficiency diseases; IRON deficiency anemia in children; INFANT diseases; HEMOGLOBINS
- Publication
Biological Trace Element Research, 2013, Vol 150, Issue 1-3, p91
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-012-9509-3