We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Lower 1,5-anhydroglucitol is associated with adverse clinical events after percutaneous coronary intervention.
- Authors
Fujiwara, Takayuki; Yoshida, Masashi; Akashi, Naoyuki; Yamada, Hodaka; Tsukui, Takunori; Nakamura, Tomohiro; Sakakura, Kenichi; Wada, Hiroshi; Arao, Kenshiro; Katayama, Takuji; Umemoto, Tomio; Funayama, Hiroshi; Sugawara, Yoshitaka; Mitsuhashi, Takeshi; Kakei, Masafumi; Momomura, Shin-ichi; Ako, Junya
- Abstract
Diabetes mellitus and impaired glucose tolerance are well-known risk factors for coronary artery disease (CAD) and adverse clinical events after percutaneous coronary intervention (PCI). Postprandial hyperglycemia is an important risk factor for CAD and serum 1,5-anhydroglucitol (1,5-AG) reflects postprandial hyperglycemia more robustly than hemoglobin (Hb)A1c. We aimed to clarify the relationship between serum 1,5-AG level and adverse clinical events after PCI. We enrolled 141 patients after PCI with follow-up coronary angiography. We evaluated associations between glycemic biomarkers including HbA1c and 1,5-AG and cardiovascular events during follow-up. Median serum 1,5-AG level was significantly lower in patients with any coronary revascularization and target lesion revascularization (TLR) [13.4 µg/ml (first quartile, third quartile 9.80, 18.3) vs. 18.7 (12.8, 24.2), p = 0.005; 13.4 µg/ml (10.2, 16.4) vs. 18.7 (12.9, 24.2), p = 0.001, respectively]. Multivariate logistic analysis showed lower 1,5-AG was independently associated with any coronary revascularization and TLR (odds ratio 0.93, 95 % confidence interval 0.86-0.99, p = 0.04; 0.90, 0.81-0.99, p = 0.044, respectively), whereas higher HbA1c was not. Postprandial hyperglycemia and lower 1,5-AG are important risk factors for adverse clinical events after PCI.
- Subjects
PERCUTANEOUS coronary intervention; SORBITOL; DIABETES; CORONARY heart disease risk factors; MYOCARDIAL revascularization; MULTIVARIATE analysis
- Publication
Heart & Vessels, 2016, Vol 31, Issue 6, p855
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-015-0682-0