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- Title
Comparison of quantitative regional perfusion-weighted phase resolved functional lung (PREFUL) MRI with dynamic gadolinium-enhanced regional pulmonary perfusion MRI in COPD patients.
- Authors
Kaireit, Till F.; Voskrebenzev, Andreas; Gutberlet, Marcel; Freise, Julia; Jobst, Bertram; Kauczor, Hans‐Ulrich; Welte, Tobias; Wacker, Frank; Vogel‐Claussen, Jens; Kauczor, Hans-Ulrich; Vogel-Claussen, Jens
- Abstract
<bold>Background: </bold>Perfusion-weighted noncontrast-enhanced proton lung MRI during free breathing is maturing as a novel technique for assessment of regional lung perfusion, but has not yet been validated in chronic obstructive pulmonary disease (COPD) patients.<bold>Purpose: </bold>To compare pulmonary parenchymal perfusion assessed by noncontrast-enhanced perfusion-weighted phase-resolved functional lung (PREFUL)-MRI with lung perfusion determined with dynamic gadolinium-enhanced (DCE)-MRI and with lung function test parameters.<bold>Study Type: </bold>Prospective.<bold>Population: </bold>A single-center subset of the COPD cohort "COPD and SYstemic consequenzes-COmorbidities NETwork" (COSYCONET). Forty-seven patients with COPD (median age 66 [57-70] years) were studied.<bold>Field Strength/sequence: </bold>For PREFUL-MRI a spoiled gradient echo sequence and for DCE-MRI, a 3D time-resolved spoiled gradient echo sequence was used at 1.5T.<bold>Assessment: </bold>PREFUL-MRI coronal slices were acquired in free breathing. DCE-MRI was performed in breath-hold with administration of 0.025 mmol/kg bodyweight of gadobutrol i.v. at a rate of 4 ml/s and pulmonary blood flow (PBF) maps were calculated. Slices of PREFUL and DCE-MRI were matched by their ventrodorsal position and corresponding slices were coregistered for evaluation. Perfusion defect percentages (QDP) were calculated for both methods.<bold>Statistical Tests: </bold>The obtained parameters were correlated using Spearman's correlation coefficient (r) and Bland-Altman plot analysis.<bold>Results: </bold>PREFUL-QDP showed an absolute and spatial agreement with PBF-QDP on a global (39.3 (31.8-45.5)% vs. 44.7 (35.4-50.0)% with a spatial overlap of 62.2 (57.2-67.2)%)) as well as on a lobar level and correlated with lung function test parameters (PREFUL-QDP vs. FEV1 , r = -0.75, P < 0.0001). There was a systematic overestimation of PREFUL-QDP compared with PBF-QDP, mainly in the lower lobes, resulting in an overall overestimation for the whole lung with a mean difference of 5% (95% confidence interval [CI]: 3.0%; 7.0%; STD 6.8%).<bold>Data Conclusion: </bold>PREFUL-MRI is a promising noninvasive, radiation-free tool for quantification of regional perfusion in COPD patients.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1122-1132.
- Publication
Journal of Magnetic Resonance Imaging, 2019, Vol 49, Issue 4, p1122
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26342