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- Title
Oxygenation-sensitive cardiovascular magnetic resonance in hypertensive heart disease with left ventricular myocardial hypertrophy and non-left ventricular myocardial hypertrophy: Insight from altered mechanics and cardiac BOLD imaging.
- Authors
Chen, Bing‐Hua; Wu, Rui; An, Dong‐Aolei; Shi, Ruo‐Yang; Yao, Qiu‐Ying; Lu, Qing; Hu, Jiani; Jiang, Meng; Deen, James; Chandra, Ankush; Xu, Jian‐Rong; Wu, Lian‐Ming; Chen, Bing-Hua; An, Dong-Aolei; Shi, Ruo-Yang; Yao, Qiu-Ying; Xu, Jian-Rong; Wu, Lian-Ming
- Abstract
<bold>Background: </bold>BOLD (blood oxygen level dependent) MRI can detect regional condition of myocardial oxygen supply and demand by means of paramagnetic properties.<bold>Purpose: </bold>Noninvasive assessment of myocardial oxygenation by BOLD MRI in hypertensive patients with hypertension (HTN) left ventricular myocardial hypertrophy (LVMH) and HTN non-LVMH and its correlation with myocardial mechanics were performed.<bold>Study Type: </bold>Prospective.<bold>Population: </bold>Twenty patients with HTN LVMH, 21 patients with HTN non-LVMH, and 23 normotensive controls were enrolled.<bold>Field Strength/sequence: </bold>Cine imaging, T2* and T1 mapping sequences were achieved at 3.0T.<bold>Assessment: </bold>Dedicated T1 mapping, T2*, and cine imaging analysis were performed by two radiologists using cvi42.<bold>Statistical Tests: </bold>One-way analysis of variance, Kruskal-Wallis test, Bland-Altman analysis, Pearson's correlation coefficient, Spearman's rank correlation.<bold>Results: </bold>T2* values of HTN LVMH group were significantly lower versus the controls (23.78 ± 3.09 versus 30.77 ± 2.71; P < 0.001) and HTN non-LVMH group (23.78 ± 3.09 versus 28.64 ± 4.23; P < 0.001). Left ventricular peak circumferential strain were reduced in HTN LVMH patients compared with other two groups (-11.32 [-15.64, -10.3], -16.78 [-19.35, -15.34], and -19.73 [-20.57, -18.73]; P < 0.05); and longitudinal strain of HTN LVMH patients were lower than other two groups (-11.31 ± 2.91, -15.1 ± 3.06, and -18.85 ± 1.85; P < 0.05); radial strain of HTN LVMH patients were also lower than other two groups (25.03 ± 16, 40.95 ± 17.5 and 47.9 ± 10.23; P < 0.05). Extracellular volume correlated with peak circumferential, longitudinal, and radial strain (spearman rho = 0.6, 0.64, and -0.69; P < 0.05), respectively; T2* negatively correlated with peak circumferential and longitudinal strain (spearman rho = -0.43 and -0.49; P < 0.05), respectively. Patients with lower T2* values had significant decreases in myocardial mechanics (P < 0.05).<bold>Data Conclusion: </bold>HTN LVMH patients have both impaired myocardial mechanics and decreased T2* values compared with HTN non-LVMH and normotensive groups. BOLD MRI could provide a feasible assessment modality for detecting altered T2* due to the change of de-oxygenated hemoglobin and hence to the change of signal intensity in oxygenation-sensitive images.<bold>Level Of Evidence: </bold>1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:1297-1306.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 48, Issue 5, p1297
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26055