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- Title
Whole-tumor apparent diffusion coefficient (ADC) histogram analysis to differentiate benign peripheral neurogenic tumors from soft tissue sarcomas.
- Authors
Nakajo, Masanori; Fukukura, Yoshihiko; Hakamada, Hiroto; Yoneyama, Tomohide; Kamimura, Kiyohisa; Nagano, Satoshi; Nakajo, Masayuki; Yoshiura, Takashi
- Abstract
<bold>Background: </bold>Apparent diffusion coefficient (ADC) histogram analyses have been used to differentiate tumor grades and predict therapeutic responses in various anatomic sites with moderate success.<bold>Purpose: </bold>To determine the ability of diffusion-weighted imaging (DWI) with a whole-tumor ADC histogram analysis to differentiate benign peripheral neurogenic tumors (BPNTs) from soft tissue sarcomas (STSs).<bold>Study Type: </bold>Retrospective study, single institution.<bold>Subjects: </bold>In all, 25 BPNTs and 31 STSs.<bold>Field Strength/sequence: </bold>Two-b value DWI (b-values = 0, 1000s/mm2 ) was at 3.0T.<bold>Assessment: </bold>The histogram parameters of whole-tumor for ADC were calculated by two radiologists and compared between BPNTs and STSs.<bold>Statistical Tests: </bold>Nonparametric tests were performed for comparisons between BPNTs and STSs. P < 0.05 was considered statistically significant. The ability of each parameter to differentiate STSs from BPNTs was evaluated using area under the curve (AUC) values derived from a receiver operating characteristic curve analysis.<bold>Results: </bold>The mean ADC and all percentile parameters were significantly lower in STSs than in BPNTs (P < 0.001-0.009), with AUCs of 0.703-0.773. However, the coefficient of variation (P = 0.020 and AUC = 0.682) and skewness (P = 0.012 and AUC = 0.697) were significantly higher in STSs than in BPNTs. Kurtosis (P = 0.295) and entropy (P = 0.604) did not differ significantly between BPNTs and STSs.<bold>Data Conclusion: </bold>Whole-tumor ADC histogram parameters except kurtosis and entropy differed significantly between BPNTs and STSs.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
- Publication
Journal of Magnetic Resonance Imaging, 2018, Vol 48, Issue 3, p680
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25987