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- Title
Comparison of global cerebral blood flow measured by phase-contrast mapping MRI with <sup>15</sup> O-H<sub>2</sub> O positron emission tomography.
- Authors
Vestergaard, Mark Bitsch; Lindberg, Ulrich; Aachmann‐Andersen, Niels Jacob; Lisbjerg, Kristian; Christensen, Søren Just; Rasmussen, Peter; Olsen, Niels Vidiendal; Law, Ian; Larsson, Henrik Bo Wiberg; Henriksen, Otto Mølby; Aachmann-Andersen, Niels Jacob; Christensen, Søren Just; Henriksen, Otto Mølby
- Abstract
<bold>Purpose: </bold>To compare mean global cerebral blood flow (CBF) measured by phase-contrast mapping magnetic resonance imaging (PCM MRI) and by 15 O-H2 O positron emission tomography (PET) in healthy subjects. PCM MRI is increasingly being used to measure mean global CBF, but has not been validated in vivo against an accepted reference technique.<bold>Materials and Methods: </bold>Same-day measurements of CBF by 15 O-H2 O PET and subsequently by PCM MRI were performed on 22 healthy young male volunteers. Global CBF by PET was determined by applying a one-tissue compartment model with measurement of the arterial input function. Flow was measured in the internal carotid and vertebral arteries by a noncardiac triggered PCM MRI sequence at 3T. The measured flow was normalized to total brain weight determined from a volume-segmented 3D T1 -weighted anatomical MR-scan.<bold>Results: </bold>Mean CBF was 34.9 ± 3.4 mL/100 g/min measured by 15 O-H2 O PET and 57.0 ± 6.8 mL/100 g/min measured by PCM MRI. The measurements were highly correlated (P = 0.0008, R2 = 0.44), although values obtained by PCM MRI were higher compared to 15 O-H2 O PET (absolute and relative differences were 22.0 ± 5.2 mL/100 g/min and 63.4 ± 14.8%, respectively).<bold>Conclusion: </bold>This study confirms the use of PCM MRI for quantification of global CBF, but also that PCM MRI systematically yields higher values relative to 15 O-H2 O PET, probably related to methodological bias.<bold>Level Of Evidence: </bold>3 J. Magn. Reson. Imaging 2017;45:692-699.
- Subjects
BRAIN physiology; BLOOD flow measurement; BRAIN; CEREBRAL circulation; COMPARATIVE studies; DIAGNOSTIC imaging; HEMODYNAMICS; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; OXYGEN; RADIOISOTOPES; RADIOPHARMACEUTICALS; RESEARCH; RESEARCH evaluation; POSITRON emission tomography; WATER; EVALUATION research; MAGNETIC resonance angiography
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 45, Issue 3, p692
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25442