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- Title
Microperfusion-induced elevation of ADC is suppressed after contrast in breast carcinoma.
- Authors
Yuen, Sachiko; Yamada, Kei; Goto, Mariko; Nishida, Kaori; Takahata, Akiko; Nishimura, Tsunehiko
- Abstract
Purpose To investigate the effect of gadolinium (Gd)-DTPA on the apparent diffusion coefficient (ADC) of breast carcinoma and to analyze the relationship between pre/postcontrast ADC and the degree of contrast enhancement. Materials and Methods Nineteen histopathologically confirmed breast carcinomas (mean size = 22 mm) were analyzed. Their ADCs before and after contrast administration were measured. The contrast-to-noise ratios (CNRs) of the tumors were measured on fat-suppressed 3D T1-weighted images in precontrast, early, and late postcontrast phases. These results were correlated with the measured ADC values. Results A significant decrease in the measured ADC was noted after contrast administration (−23%, P = 0.01). Lesions with relatively high ADC before contrast (>1.3 × 10−3 mm2/sec; n = 12) demonstrated a larger degree of ADC reduction (mean 34%) than lesions with low ADC (≤1.3 × 10−3 mm2/sec; n = 7) (mean 4.5%). When an early postcontrast image was used as a surrogate marker of malignant potential, we found a significant inverse correlation with postcontrast ADC (γ = −0.57, P = 0.02). Conclusion Postcontrast ADC exhibited lower values than precontrast ADC, which is thought to reflect suppression of the microperfusion-induced effect on diffusion-weighted imaging. Postcontrast ADC may be a better indicator than precontrast ADC to reflect malignant potential of tumors. J. Magn. Reson. Imaging 2009;29:1080-1084. © 2009 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2009, Vol 29, Issue 5, p1080
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.21743