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- Title
Preclinical Activities of Epigallocatechin Gallate in Signaling Pathways in Cancer.
- Authors
Sharifi-Rad, Mehdi; Pezzani, Raffaele; Redaelli, Marco; Zorzan, Maira; Imran, Muhammad; Ahmed Khalil, Anees; Salehi, Bahare; Sharopov, Farukh; Cho, William C.; Sharifi-Rad, Javad; Bettuzzi, Saverio
- Abstract
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins predominantly present in various types of tea. EGCG is well known for a wide spectrum of biological activities as an anti-oxidative, anti-inflammatory, and anti-tumor agent. The effect of EGCG on cell death mechanisms via the induction of apoptosis, necrosis, and autophagy has been documented. Moreover, its anti-proliferative action has been demonstrated in many cancer cell lines. It was also involved in the modulation of cyclooxygenase-2, oxidative stress and inflammation of different cellular processes. EGCG has been reported as a promising agent target for plasma membrane proteins, such as epidermal growth factor receptor. In addition, it has been demonstrated a mechanism of action relying on the inhibition of ERK1/2, p38 MAPK, NF-κB, and vascular endothelial growth factor. Furthermore, EGCG and its derivatives were used in proteasome inhibition and they were involved in epigenetic mechanisms. In summary, EGCG is the most predominant and bioactive constituent of tea and may play a role in cancer prevention.
- Subjects
EPIGALLOCATECHIN gallate; EPIDERMAL growth factor receptors; VASCULAR endothelial growth factors; BLOOD proteins; MEMBRANE proteins
- Publication
Molecules, 2020, Vol 25, Issue 3, p467
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25030467