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- Title
Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors.
- Authors
Xing-Yue Ji; Hui-Qiang Wang; Lan-Hu Hao; Wei-Ying He; Rong-Mei Gao; Yan-Ping Li; Yu-Huan Li; Jian-Dong Jiang; Zhuo-Rong Li
- Abstract
A series of novel N-phenylbenzamide derivatives were synthesized and their anti-EV 71 activities were assayed in vitro. Among the compounds tested, 3-amino-N-(4- bromophenyl)-4-methoxybenzamide (1e) was active against the EV 71 strains tested at low micromolar concentrations, with IC50 values ranging from 5.7 ± 0.8-12 ± 1.2 μM, and its cytotoxicity to Vero cells (TC50 = 620 ± 0.0 μM) was far lower than that of pirodavir (TC50 = 31 ± 2.2 μM). Based on these results, compound 1e is a promising lead compound for the development of anti-EV 71 drugs.
- Subjects
ANTIVIRAL agent synthesis; ENTEROVIRUS diseases; ORGANIC compound derivatives; ANTIBODY-dependent cell cytotoxicity; LEAD compounds; PREVENTION; THERAPEUTICS
- Publication
Molecules, 2013, Vol 18, Issue 3, p3630
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules18033630