We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Replacement of oxytocin bolus administration by infusion: influences on postpartum outcome.
- Authors
Löytved-Hardegg, Julia; Brunner, Mirjam; Ries, Jean-Jacques; Felten, Stefanie; Heugel, Christina; Lapaire, Olav; Voekt, Cora; Hösli, Irene; Löytved-Hardegg, Julia J; von Felten, Stefanie; Hösli, Irene
- Abstract
<bold>Purpose: </bold>Postpartum haemorrhage (PPH) represents a leading cause of maternal morbidity and mortality. Giving oxytocin after birth reduces the risk for PPH. It has never been tested whether different methods of oxytocin administration affect the maternal outcome. This study aims to compare the infusion versus the bolus application of oxytocin after singleton vaginal delivery.<bold>Methods: </bold>This retrospective monocentre study compares the incidence of clinically relevant postpartum complications in women receiving 5 IE of oxytocin as a bolus or as a 100 ml-infusion over 5 min, given immediately after birth. Included were women delivering singletons vaginally at term. We used propensity score weighting to compare outcomes between women receiving bolus and infusion and to minimize the selection bias in this retrospective cohort.<bold>Results: </bold>1765 patients were included. Patient characteristics were balanced. We found no significant differences for the combined overall postpartum adverse outcome (the incidence of PPH, manual removal of the placenta and/or curettage). For the single outcomes, we observed a significantly higher frequency of manual removal of the placenta (Odds ratio 1.47, 95 % CI 1.02-2.13) and a slightly higher but clinically not relevant estimated blood loss (Relative effect 1.05, 95 % CI 1.01-1.10) in the infusion group.<bold>Conclusion: </bold>The data show a tendency towards more complications in the infusion group. It is related to a more frequent need for manual removal of the placenta.
- Subjects
PUERPERAL disorders; MATERNAL mortality; BOLUS drug administration; OXYTOCIN; INFUSION therapy; RETROSPECTIVE studies; THERAPEUTICS; COMPARATIVE studies; DELIVERY (Obstetrics); HEMORRHAGE; LABOR (Obstetrics); LABOR complications (Obstetrics); RESEARCH methodology; EVALUATION of medical care; MEDICAL cooperation; PLACENTA diseases; PREGNANCY; PUERPERIUM; RESEARCH; EVALUATION research; OXYTOCICS
- Publication
Archives of Gynecology & Obstetrics, 2016, Vol 293, Issue 6, p1219
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-015-3916-6