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- Title
A tutorial on statistical methods for population association studies.
- Authors
Balding, David J.
- Abstract
Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including preliminary analyses (Hardy-Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. My goal is to outline the key methods with a brief discussion of problems (population structure and multiple testing), avenues for solutions and some ongoing developments.
- Subjects
GENETIC research; DEMOGRAPHIC surveys; CLINICAL trials; ASSOCIATIONS, institutions, etc.; STATISTICS
- Publication
Nature Reviews Genetics, 2006, Vol 7, Issue 10, p781
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg1916