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- Title
Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases.
- Authors
Takahashi, Takehiro; Asano, Yoshihide; Amiya, Eisuke; Hatano, Masaru; Tamaki, Zenshiro; Ozeki, Atsuko; Watanabe, Aya; Kawarasaki, Shuichi; Nakao, Tomoko; Taniguchi, Takashi; Ichimura, Yohei; Toyama, Tetsuo; Watanabe, Masafumi; Hirata, Yasunobu; Nagai, Ryozo; Sato, Shinichi
- Abstract
Intravenous cyclophosphamide pulse therapy (IVCY) exerts its efficacy against interstitial lung disease (ILD) associated with systemic sclerosis (SSc) by restoring vascular injuries as well as aberrant immune activation. We recently experienced two patients with SSc-ILD in whom the values of brachial flow-mediated dilation (FMD) reflected the efficacy of IVCY. We herein report the details of these cases and discuss the potential of FMD to predict and evaluate the effect of IVCY on SSc-ILD.
- Subjects
PULMONARY fibrosis treatment; ENDOTHELIUM physiology; DYSPNEA; INTRAVENOUS therapy; CYCLOPHOSPHAMIDE; SYSTEMIC scleroderma
- Publication
Modern Rheumatology, 2012, Vol 22, Issue 4, p598
- ISSN
1439-7595
- Publication type
Article
- DOI
10.3109/s10165-011-0545-1