We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention.
- Authors
Zhang, Zhenyu; Chen, Minnan; Zhan, Wenjing; Chen, Yuechun; Wang, Tongtong; Chen, Zhonghua; Fu, Yifei; Zhao, Gang; Mao, Dong; Ruan, Jingjing; Yuan, Feng-Lai
- Abstract
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.
- Subjects
ACID-sensing ion channels; PERIPHERAL nervous system; APOPTOSIS; DISEASE progression; RHEUMATOID arthritis; NEUROLOGICAL disorders; WNT signal transduction
- Publication
Cell Death Discovery, 2023, Vol 9, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-023-01624-6