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- Title
Association of DNA Polymorphisms in the Synaptic Vesicular Amine Transporter Gene (SLC18A2) with Alcohol and Nicotine Dependence.
- Authors
Schwab, Sibylle G.; Franke, Petra E.; Hoefgen, Barbara; Guttenthaler, Vera; Lichtermann, Dirk; Trixler, Matyas; Knapp, Michael; Maier, Wolfgang; Wildenauer, Dieter B.
- Abstract
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.Neuropsychopharmacology (2005) 30, 2263–2268. doi:10.1038/sj.npp.1300809; published online 29 June 2005
- Subjects
GENETIC polymorphisms; ALCOHOLISM; NICOTINE addiction; SUBSTANCE abuse; DOPAMINE; SEROTONIN; NEUROPSYCHOPHARMACOLOGY
- Publication
Neuropsychopharmacology, 2005, Vol 30, Issue 12, p2263
- ISSN
0893-133X
- Publication type
Article
- DOI
10.1038/sj.npp.1300809