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- Title
Associations between single nucleotide polymorphism in the Dgat2 gene and several ecnomic traits in commercial feedlot steers.
- Authors
Li, J.; Xu, X.; Zhang, Q.; Wang, X.; Deng, G.; Fang, X.; Gao, X.; Ren, H.; Zhang, L.; Pollak, E. J.; Quaas, R. L.; Xu, S.
- Abstract
DGAT2 was found to be a new diacylgycerol acyltransferase gene family in 2001. It plays more important role in mammalian triglyceride metabolism than DGAT1 does, but associations between DGAT2 and beef cattle economic merits have not been reported. The objective of this study was to try to find single nucleotide polymorphisms (SNP) with PCR-SSCP method in bovine DGAT2 gene and evaluate the association of that with carcass and meat quality traits from 157 commercial feedlot steers distributing to 3 Chinese local breeds and 4 cross breeds. In this study, 15 SNP have been discovered in the Dgat2 Intron3 (GenBank Accession No. AY589091) at positions 65, 128, 178, 210, 241, 255, 270, 312, 328, 334, 365, 366, 371, 415 and 437 (Named as their position in PCR amplified fragments). Only 7 of them were analyzed (128, 178, 241, 270, 312, 328 and 371), because three groups (65-128-255, 178-210-365 and 241-334-366) were in complete linkage disequilibrium within group, SNP at position 415bp is a mutation of deletion and that at position 437bp is a null mutation. These data were analyzed using two different models, 1) genotype, and 2) allele substitution. Contemporary groups were fit as a fixed effect and formed from feed group in feedlot plus breed type. Significant statistics are listed in table 1. An initial conclusion was that associations exist between DGAT2 gene and several beef cattle economic traits that concern with carcass fat. For the small sample size of this study, proposal is further effort should be required to validate these findings in larger populations.
- Subjects
SINGLE nucleotide polymorphisms; GENETIC polymorphisms; BEEF cattle; GENE families; LINKAGE disequilibrium; MEAT quality
- Publication
Journal of Animal Science, 2006, Vol 84, p448
- ISSN
0021-8812
- Publication type
Article