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- Title
On a bender--BARs, ESCRTs, COPs, and finally getting your coat.
- Authors
Field, Mark C.; Sali, Andrej; Rout, Michael P.
- Abstract
Tremendous variety in form and function is displayed among the intracellular membrane systems of different eukaryotes. Until recently, few clues existed as to how these internal membrane systems had originated and diversified. However, proteomic, structural, and comparative genomics studies together have revealed extensive similarities among many of the protein complexes used in controlling the morphology and trafficking of intracellular membranes. These new insights have had a profound impact on our understanding of the evolutionary origins of the internal architecture of the eukaryotic cell.
- Subjects
EUKARYOTIC cells; GENOMICS; PROTEINS; GENETICS; MOLECULAR genetics
- Publication
Journal of Cell Biology, 2011, Vol 193, Issue 6, p963
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.201102042