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- Title
Clinical Efficacy and Safety of Vancomycin Continuous Infusion in Patients Treated at Home in an Outpatient Parenteral Antimicrobial Therapy Program.
- Authors
Thijs, Lore; Quintens, Charlotte; Vander Elst, Lotte; De Munter, Paul; Depypere, Melissa; Metsemakers, Willem-Jan; Vles, Georges; Liesenborghs, Astrid; Neefs, Jens; Peetermans, Willy E.; Spriet, Isabel
- Abstract
Vancomycin is commonly used in outpatient parenteral antimicrobial therapy (OPAT) of Gram-positive infections. Therapeutic drug monitoring and adverse event monitoring pose a challenge. Outcome data of vancomycin in OPAT (vOPAT) are limited. The study aim was to report the safety and efficacy of a structured vOPAT program implemented in the University Hospitals Leuven. The program provides continuous elastomeric infusion of vancomycin at home with biweekly follow-up at the outpatient clinic. Demographics, clinical, biochemical and treatment parameters, target attainment parameters and clinical outcomes were recorded. An e-survey was conducted to assess patient satisfaction. Thirty-five vOPAT episodes in 32 patients were included. During 206 follow-up consultations, 203 plasma concentration measurements were registered with a median vancomycin plasma concentration of 22.5 mg/L (range 6.6–32.0). The majority of concentrations (68.5%) were within the therapeutic range (20.0–25.0 mg/L). Adverse event rates, including drug- (5.7%) and catheter-related (5.7%) events, were low. For 32 vOPAT episodes, a clinical cure rate of 100% was observed. All patients who completed the e-survey were satisfied with their vOPAT course. These findings show that a structured vOPAT program with rigorous follow-up provides safe and effective ambulatory treatment of patients with vancomycin in continuous infusion.
- Subjects
PARENTERAL therapy; DRUG monitoring; VANCOMYCIN; PATIENT satisfaction
- Publication
Antibiotics (2079-6382), 2022, Vol 11, Issue 5, p702
- ISSN
2079-6382
- Publication type
Article
- DOI
10.3390/antibiotics11050702