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- Title
Vaccination against SARS-CoV-2 Does Not Protect against the Development of Anosmia in a Hamster Model.
- Authors
Reyna, Rachel A.; Walker, Jordyn; Mitchell, Brooke; Shinde, Divya P.; Plante, Jessica A.; Weaver, Scott C.; Plante, Kenneth S.
- Abstract
Anosmia, a total or partial loss of the ability to smell, is one of the most frequently documented sequelae of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Persistent anosmia is associated with a decrease in quality of life. Here, we assess the impact of virus lineage and vaccination status on anosmia development in the golden Syrian hamster model. To characterize anosmia driven by current variants, we assessed olfactory function in hamsters infected with SARS-CoV-2 lineages A, BA.2, BA.5, BQ.1, and BQ.1.1 using a buried food detection test. We found that significant anosmia occurs upon infection with all variants with a significant correlation between disease severity and degree of anosmia. Moreover, we found that vaccination with either the Pfizer (BNT16b2) or Moderna (mRNA-1273) mRNA vaccines does not protect against anosmia, despite protection against severe disease.
- Subjects
PFIZER Inc.; SARS-CoV-2; GOLDEN hamster; HAMSTERS; VACCINATION status; VACCINATION
- Publication
Vaccines, 2023, Vol 11, Issue 10, p1564
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines11101564