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- Title
Sex and Socioeconomic Disparities in Dementia Risk: A Population-Attributable Fraction Analysis in Argentina.
- Authors
Calandri, Ismael Luis; Livingston, Gill; Paradela, Regina; Ossenkoppele, Rik; Crivelli, Lucia; Allegri, Ricardo F.; Suemoto, Claudia K.
- Abstract
Introduction: Twelve modifiable risk factors (RFs) account for 40% of dementia cases worldwide. However, limited data exist on such factors in middle- and low-income countries. We aimed to estimate the population-attributable fractions (PAFs) for the 12 RFs in Argentina, assessing changes over a decade and exploring socioeconomic and sex influences. Methods: We conducted cross-sectional analyses of the 12 RFs from Argentinian surveys conducted in 2009, 2015, and 2018, including 96,321 people. We calculated PAFs and stratified estimates based on sex and income. Results: We estimated an overall PAF of 59.6% (95% CI = 58.9–60.3%). The largest PAFs were hypertension = 9.3% (8.7–9.9%), physical inactivity = 7.4% (6.8–8.2%), and obesity = 7.4% (6.8–7.9%). Men were more impacted by excessive alcohol, while women by isolation and smoking. Lower income linked to higher PAFs in education, hypertension, and obesity. Discussion: Argentina has a higher PAF for dementia than the world population, with distinct RF distribution. PAF varied by sex and economic status, advocating tailored prevention strategies.
- Subjects
ARGENTINA; SEX factors in disease; LOW-income countries; DISEASE risk factors; SEDENTARY behavior; ECONOMIC status
- Publication
Neuroepidemiology, 2024, Vol 58, Issue 4, p264
- ISSN
0251-5350
- Publication type
Article
- DOI
10.1159/000536524