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- Title
Large volume polymerized haemoglobin solution in a Jehovah's Witness following abruptio placentae.
- Authors
Cothren, C. C.; Moore, E. E.; Long, J. S.; Haenel, J. B.; Johnson, J. L.; Ciesla, D. J.
- Abstract
Severe anaemia, with haemoglobin (Hb) levels ≤3 g dL−1, is associated with mortality rates of 50–95%. Although accepted transfusion targets have been debated in the literature ( ; ; ; ), few would argue the risks associated with Hb levels less than 5 g dL−1 in critically ill patients. In patients who are unable to receive red blood cell transfusions, the utility of Hb solutions is an attractive solution. We describe a Jehovah's Witness patient who exemplifies the marked physiologic derangements of severe anaemia and subsequent clinical resolution with large volume polymerized human Hb transfusion. The Hb-based oxygen carrier, PolyHeme®, provided adequate oxygen transport, acting as a bridge until endogenous production could compensate for red cell loss. Practicing physicians need to be aware of current therapeutic options for use in these complicated patients.
- Subjects
BLOOD substitutes; BLOOD transfusion; JEHOVAH'S Witnesses; LABOR complications (Obstetrics); THERAPEUTICS; RELIGION
- Publication
Transfusion Medicine, 2004, Vol 14, Issue 3, p241
- ISSN
0958-7578
- Publication type
Article
- DOI
10.1111/j.0958-7578.2004.00502.x