We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A new autosomal recessive nonsyndromic hearing impairment locus DFNB96 on chromosome 1p36.31-p36.13.
- Authors
Ansar, Muhammad; Lee, Kwanghyuk; Naqvi, Syed Kamran-ul-Hassan; Andrade, Paula B; Basit, Sulman; Santos-Cortez, Regie Lyn P; Ahmad, Wasim; Leal, Suzanne M
- Abstract
A novel locus for autosomal recessive nonsyndromic hearing impairment (ARNSHI), DFNB96, was mapped to the 1p36.31-p36.13 region. A whole-genome linkage scan was performed using DNA samples from a consanguineous family from Pakistan with ARNSHI. A maximum two-point logarithm of odds (LOD) score of 3.2 was obtained at marker rs8627 (chromosome 1: 8.34 Mb) at θ=0 and a significant maximum multipoint LOD score of 3.8 was achieved at 15 contiguous markers from rs630075 (9.3 Mb) to rs10927583 (15.13 Mb). The 3-unit support interval and the region of homozygosity were both delimited by markers rs3817914 (6.42 Mb) and rs477558 (18.09 Mb) and contained 11.67 Mb. Of the 125 genes within the DFNB96 interval, the previously identified ARNSHI gene for DFNB36, ESPN, and two genes that cause Bartter syndrome, CLCNKA and CLCNKB, were sequenced, but no potentially causal variants were identified.
- Subjects
HEARING disorders; GENETIC disorders; DNA; HUMAN genetic variation; CHROMOSOME abnormalities; BARTTER syndrome
- Publication
Journal of Human Genetics, 2011, Vol 56, Issue 12, p866
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2011.110