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- Title
cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18.
- Authors
Azuma, T.; Seki, N.; Yoshikawa, T.; Saito, T.; Masuho, Y.; Muramatsu, M.
- Abstract
Abstract The SRY (sex-determining region Y) gene encodes a transcription factor characterized by a DNA-binding motif termed the HMG (high mobility group) domain. The SOX (Sry-box) genes comprise a large family related by homology to the HMG-box region. We isolated a cDNA clone with an open reading frame encoding a putative protein of 384 amino acids, which shared 83% identity to the mouse Sox18 protein. Northern blot analysis revealed that a 1.9-kb band of human SOX18 messenger RNAs was predominantly expressed in heart, although weak signals were seen in brain, liver, testis, and leukocyte. By polymerase chain reaction (PCR)-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel, the gene was mapped to the chromosome 20q13.33 region.
- Subjects
HUMAN sexuality; TRANSCRIPTION factors; CHROMOSOMAL proteins; GENE mapping
- Publication
Journal of Human Genetics, 2000, Vol 45, Issue 3, p192
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380050210