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- Title
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.
- Authors
Kurhade, Chaitanya; Schreier, Sarah; Yi-Ping Lee; Zegenhagen, Loreen; Hjertqvist, Marika; Dobler, Gerhard; Kröger, Andrea; Överby, Anna K.; Lee, Yi-Ping
- Abstract
We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
- Subjects
TICK-borne diseases; MICROBIAL virulence; ENCEPHALITIS; CYTOKINES; CELLULAR immunity; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; EPIDEMIC encephalitis; FLAVIVIRUSES; IMMUNITY; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; EVALUATION research; SEVERITY of illness index
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 9, p1709
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2409.171825