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- Title
R292K substitution and drug susceptibility of influenza A(H7N9) viruses.
- Authors
Sleeman, Katrina; Guo, Zhu; Barnes, John; Shaw, Michael; Stevens, James; Gubareva, Larisa V
- Abstract
Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.
- Publication
Emerging Infectious Diseases, 2013, Vol 19, Issue 9, p1521
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid1909.130724